Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
The film critics of The New York Times — Manohla Dargis and A. O. Scott — share their picks for the best movies of the year.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
In this Jan. 9, 2007 file phtoo, Apple CEO Steve Jobs holds up an Apple iPhone at the MacWorld Conference in San Francisco. Jobs the CEO,
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上，库克被应用开发者团团围住，要求与他自拍合影。到了10月的iPad发布会，他甚至自己讲起了笑话。他还是一贯的着装，简单朴实：黑衬衫，牛仔裤，衬衫下摆散着。他说，Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评，一边说，一边心照不宣地指着轻声发笑的观众。
Historians now hope to dispel some of the myths about Richard, publicising evidence to refute claims that he killed the two young princes and focusing on what he achieved in his brief two-year reign, including the establishment of a system of bail and legal aid.
A network of walking and biking trails leads to other lakeside neighborhoods and to downtown, which is about 15 minutes by bicycle and 10 by car. The Walker Art Center and other museums are nearby. Hockey and skating are popular on the lakes in winter; canoeing, swimming and fishing in the summer.
Trends and targets in antiviral phototherapy
They expect the heat to get much worse over coming decades, but already it is killing forests around the world, driving plants and animals to extinction, melting land ice and causing the seas to rise at an accelerating pace.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
The ranking includes schools from 26 countries, including 35 in the US, 10in the UK and nine in China. Renmin University of China School of Business in Beijing rose furthest, climbing 18 places to 43rd. Four schools made it into the ranking for the first time. These are led by Cambridge Judge Business School at 36th. France’s Grenoble Business School is ranked 70th, Turkey’s Sabanci University School of Management is at99th, and Brazil’s Coppead is at 100th.
Novel biosensing methodologies for ultrasensitive detection of viruses
To ease women's concerns following the implementation of the two-child policy, the country should put in place more explicit regulations banning discrimination against women. These could include requiring companies to have a certain percentage of female employees, as well as tax cuts or other preferential measures to encourage employers to effectively implement the extended maternity leave regulation for female workers.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Besides, Japan and the United States are still innovation hot spots and chemical, semiconductor and electronic components and autos are the top innovative industries, according to the report.
Then why do you go out and do the things you tell us not to do? 你们大人为什么去做与你们教导孩子相反的事情呢？
Diagnostic technologies for COVID-19: a review
For over two decades I have been writing about the rise of Asia and the dynamic driving it. There is an extraordinary consensus among east Asian leaders that Asia needs to use this window of opportunity to focus on economic development and growth. War is the biggest obstacle to development. If Asians were truly stupid, they would engage in such wars and derail their enormous development promise. Most Asian leaders, barring North Korea, understand well the dangers of war. Hence, while there will be tensions and rivalries in the region, there will be no wars in the region, in 2014 or in 2015. As 2015 unfolds, I would like to encourage all western pundits to understand the underlying Asian dynamic on its own terms, and not on the basis of western preconceptions.
The special tokens of appreciation will take place alongside more traditional and somber observances, including the laying of a wreath by President Barack Obama at the Tomb of the Unknown Soldier at Arlington National Cemetery, just across the Potomac River from the nation's capital.
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Among the 18 sectors categorized by the China Securities Regulatory Commission, financial executives ranked the highest with annual pay of 27.36 million yuan, followed by real estate executives at 11.18 million yuan.
The bulk was due to underlying global warming caused largely by rising emissions of carbon dioxide, the main man-made greenhouse gas produced by burning fossil fuels, such as coal and oil.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
One such development is 60 Water Street in Dumbo, a 290-unit rental with a 24-hour concierge and a roof deck offering Manhattan views. Leasing begins next month, with rent for a two-bedroom starting at a jaw-dropping $6,018 a month. “People want that condo-like living, even though they’re renting and not owning,” said Jodi Ann Stasse, the managing director of new developments for Citi Habitats.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
AFI Movies of the Year
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
While the WeChat use of the "post-90s" generation has slightly decreased, from 94.1 percent to 86.6 percent.
To make sure the plan goes through, the central government must reinforce the plan to co-ordinate basic pension, enhance enterprise annuity and manage personal accounts properly, Yang said.
Influenza neuraminidase: A druggable target for natural products
“He’s had more of a sense of swagger and confidence” in recent months, says Jan Dawson of Jackdaw Research.
A woman's portrait has not been printed on U.S. paper money since 1896, when Martha Washington, the wife of the first U.S. president, was shown on a one dollar silver certificate.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Demagogues are the Achilles heel of democracy.
The role of biosensors in the detection of emerging infectious diseases
Last year was the hottest on earth since record-keeping began in 1880, scientists reported on Friday, underscoring warnings about the risks of runaway greenhouse gas emissions and undermining claims by climate change contrarians that global warming had somehow stopped.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Jacobs vowed at the meeting to improve management and cooperation with the association to enhance the credibility of the science. He stressed the publisher was not targeting China, as it had also retracted papers by experts from other countries, the statement said.
With U.S. e-commerce activity approaching 10% of all retail sales, more merchants are shopping around for easy-to-use platforms that get them selling online quickly.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
华特迪士尼公司(Walt Disney)首席执行官、自2011年起成为苹果董事会成员的鲍勃?伊格尔(Bob Iger)说：“人们说他外表冷淡，但他是个非常有激情的男人，而且勇于站出来捍卫自己的信仰。无论对个人生活还是对苹果，他都是如此。”
Inhibition of SARS coronavirus helicase by bismuth complexes
Instead it ticked upward slightly to 8.3 per cent.
We asked the Dachis Group, a social media measurement agency, to tell us which brands got the biggest increases in consumer love, and which lost the most ground.
Skeptics of climate change have long argued that global warming stopped around 1998, when an unusually powerful El Ni?o produced the hottest year of the 20th century. Some politicians in Washington have seized on that claim to justify inaction on emissions.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
“These kinds of questions are really front and center, even though they’re not necessarily verbalized.”
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
By contrast, the strengthening of the Brazilian real helped the surge in coffee and sugar prices as the country is the largest producer of both.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
While Switzerland’s University of St Gallen retains the top spot, French and British business schools, with 24 and 18 programmes respectively, are the backbone of the 2017 FT ranking of 95 programmes around the world. More than half of UK schools move up the ranking, compared with one in France. A third of British schools rise five places, in contrast to the two-thirds of French schools that drop five or more places.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Russian President Vladimir Putin took a 10% pay cut last year, as his country sank into a deep recession. But that was after his salary more than doubled in April 2014, to roughly 9.7 million rubles.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
You’re a busy person. At times, it all can feel overwhelming. Asana is a cloud-based project management software that helps you keep it together. (Trust me, I’ve tried them all.) Flexibility is built into Asana’s architecture. Each “task”, or “subtask”, can be associated with a larger “project” and “department.” In addition, you can even assign recurring tasks to yourself or team, which makes life so much easier. Stop trying to remember all the things you’re supposed to do and let Asana structure your life.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
"Demolitions are now becoming increasingly terrible. I am willing to ask a question very seriously as a CPPCC National Committee member: Can we not pay so much attention to GDP? Can we choose to slow down the speed of economic development?" CUI YONGYUAN, member of the CPPCC National Committee and TV host
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
尽管在2008 年9 月被任命为美国时代华纳集团旗下《型时代》杂志总编辑的阿里尔·福克斯曼是榜单新人，很少参加电视节目，但他的时尚总监哈尔·鲁本斯坦现在是美国“一生” 女性频道《幻彩魔刷：寻找下一个化妆大师》节目的评委。福克斯曼的刊物在广告页数上领先，据称在2009 年上半年总计超过1000 页。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
17. Most Complex Hurdle As of Dec. 7, seven out of 20 domestic top-grossing movies released this year had female-driven stories, according to the website Box Office Mojo. By contrast, five out of 20 female-driven stories topped the international market, which accounts for some 70 percent of the industry’s revenue. This may look bad, but the numbers appear marginally better than they have in recent years.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
会计和咨询机构德勤(Deloitte)英国分公司的企业责任主管克莱尔?伯顿(Claire Burton)表示，Teach First出来的人很受招聘人员的欢迎，因为他们擅长团队合作，有很强的领导能力。
This raises the risk of heavy rains and flooding, scientists pointed out, because warmer temperatures would lead to more water vapour in the world’s atmosphere.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
As for bitcoin in the mainstream banking system? “We are still a good year away, in our estimation, from where you can imagine a known financial services company using this,” Ludwin says. “But it’s not 10 years. And when it happens, people will be surprised by how quickly it spreads.”
Rossi, 31, spends his days calculating the future costs of the Pentagon's pension, health and education benefits, but says his job involves more than just crunching numbers for spreadsheets. He communicates with other government agencies and brainstorms with colleagues about financial models.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
“I think the best way to engage young people in the process is to win,” he says.
The China Association of Automobile Manufacturers announced on Friday that passenger car sales totaled 2.2 million units in January, 9.3 percent more than a year earlier, and the production of new-energy vehicles surged by 144 percent.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Since merged airlines often continue to report delay statistics separately, it may take a few years to see how the new American does during holiday travel.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Here, you may be delegates of your governments, business people, organisers, reporters or poiticians - but really you are mothers and fathers, brothers and sister, aunts and uncles - and all of you are somebody's child. 在这里，您可能是您政府商业人士的代表、组织者、记者或政客。但您们也是父亲和母亲、兄弟和姐妹、阿姨和叔叔，你们都会或多或少的为了下一代而活着。
He then proceeded to ram the violin through the canvas.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Cross talk “Do Not Blame Me” (Cao Yunjin and Liu Yuntian)
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
We were forced to leave our comfort zone but were rewarded with unique experiences, says one graduate.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
"Nobody can stop it. I will keep sending leaflets into North Korea at the risk of my life," Park said, adding he has always prepared to face down the North's threats.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Did you have to worry about these little things when you were my age? 在您那个年代，您曾经担心过我们现在担心的事吗？
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
The studio says it has taken the step because the boy declined to remove a YouTube video he published which promoted how to use the software.
Companies that cut support roles during the downturn, the report notes, will be "adding staff to help make departments more productive and efficient." That trend may herald a happy new year for job hunters.
贾斯汀比伯名列第五，因他为慈善组织Pencils of Promise和Believe Charity Drive做的贡献。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
今日，麦高恩在杂志Sunday Times Magazine上对性侵维权运动做出不雅评论，头一天布雷特·卡瓦诺法官刚在最高法院中宣誓就职，并于当天否认了性侵控告。
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
A review of our work in 2016
PRRI research director Daniel Cox said that some respondents - including 75 percent of non-white Protestants - believe extreme weather is both evidence of end times and the result of climate change.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
A lone European telephone bidder paid a top price of 9.1 million for a smaller 1825 version of John Constable’s admired but difficult-to-love 1824 vertical landscape, “The Lock,” that had been in the same British family since 1855.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道，我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动！
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Concerns about the vulnerability of some emerging economies and gyrations in financial markets over the past few days should not dent “cautious optimism” about the global economy this year, leading central bankers and officials said on Saturday.
Anti-HIV drug repurposing against SARS-CoV-2
For: A huge box office hit that could benefit from a slowly-changing Oscar voting demographic.
Only 6.92 percent of Hawaiian’s flights arrived late during the past three years, almost twice as good as the runner up, Alaska Air — 11.27 percent of its flights arrived late.
BROADCHURCH (BBC America, March 4) David Tennant returns in the second season of this evocative British mystery, playing Detective Alec Hardy again (after a season as Detective Emmett Carver in the American remake, “Gracepoint”). With the British premiere scheduled for Monday, the producers have begun to talk a little about the show’s top-secret Season 2 story line, and fans may not like what they hear: Chris Chibnall, the creator and writer, told a British magazine, “It’s not another crime case.” Olivia Colman returns as Detective Ellie Miller, while Charlotte Rampling and Marianne Jean-Baptiste join the cast.
Length-scale dependence of protein hydration-shell density
It's a tall order, but if you want to go after one of the thousands of supply-chain jobs that are going begging, a solid start would be logistics training, available at many colleges and universities. Some programs, like Penn State's graduate certificate in supply chain management, are offered online.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
But what will politicians actually do While President Trump is focused on bringing back traditional manufacturing jobs to America, different US states are experimenting with other policies to help low-paid precarious workers. These range from sharply higher minimum wages to new rules to stop employers changing staff schedules at the last minute.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Heatwaves around the world, including one in India that led to more than 2,000 deaths and another in Iraq that saw the mercury top 50C, helped push temperatures 1C above pre-industrial levels for the first time, US and UK researchers said.
达洛伊西奥的父母从澳大利亚搬到英国，他的父亲卢(Lou)曾在英国石油(BP)和摩根士丹利(Morgan Stanley)工作，而母亲戴安娜(Diana)是一位企业律师，同时也是儿子的合同代表。他们向来都知道达洛伊西奥是一个非常好学的孩子。但戴安娜说因为他是长子，他们本以为他不会做出什么超出寻常的事情来（达洛伊西奥有一个14岁的弟弟）。他们强调，尽管达洛伊西奥成就非凡，尽管他聊天时会聊起马尔科夫模型(Markov models)和随机过程(stochastic processes)，他仍只是一个再普通不过的孩子。戴安娜说，他周末仍要出去玩，仍要去参加派对。他还有个女朋友。17岁孩子会做的事情，他都会做。
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A Florida teen is causing strangers to freeze and stare because of her uncanny likeness to Queen Elsa from the Disney movie Frozen.