Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Swiss school IMD comes top in the ranking of open-enrolment courses, available to all working managers, and jumps two places to second for customised programmes, which are tailor-made for corporate customers. Iese of Spain holds on to the top spot in the custom ranking and remains second in the open ranking.
Directing for a Comedy Series: Jill Soloway, “Transparent” (“Man on the Land”)
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Its return to the throne came at a cost to London which, after occupying pole position for two years, is trading places with its Asian rival.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
"An institution's global outlook is one of the key markers of a prestigious university. The top institutions hire faculty from all over the world, attract students from a global market of top talent and collaborate with leading departments wherever they happen to be based." said Phil Baty, editor of Times Higher Education World University Rankings.
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
If successful, Hurun estimates that Mr Wang’s net worth could soar past $50bn, making him one of the world’s 10 richest men.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Trends and targets in antiviral phototherapy
The Cnzz.com report states that almost two-thirds of China's 338 million Web users are now online game players. The online game industry, which currently accounts for more than half of the total Internet economy, will see strong annual growth at a rate of 20% in future years, the report says.
中国商务部(Ministry of Commerce)表示，今年1-10月中国对外投资总计863亿美元。
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
In 2011, some seven years after the last season of Friends, over 36 million tuned into Comedy Central, a US satellite TV channel, to watch the show. The main demographic for this channel is 16 to 34 year olds, and viewing figures spiked during holidays, when extra episodes are also shown.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
美国大学与雇主协会（National Association of Colleges and Employers）进行的一项新研究表明，48%的美国公司计划于2011年招募物流专业研究生。供应链管理人才稀缺的现象，恰恰印证了这一调研结果。
ACE2 as a potential therapeutic target for pandemic COVID-19
In 2013, the yen fell 21% against the U.S. dollar, helping it to attract 10 million overseas tourists--including, despite Sino-Japanese border disputes in the East China Sea, many wealthy travelers from China.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
McGowan has also hit out at Meryl Streep, saying that it is 'literally impossible' the actress knew nothing of Weinstein's sexual proclivities until last autumn.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Some hits have gone so far over the top they should be winded, yet instead keep on puffing gusts of hot air, including “Downton Abbey,” “Scandal” and “Revenge.” A new addition on ABC, “How to Get Away With Murder” was a fun substitute, a lurid nighttime soap opera about lawbreaking defense lawyers — “Law & Disorder.”
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
在销量方面，通用和福特的部分市场份额被克莱斯勒蚕食，后者已经把Jeep品牌成功提升到此前难以想象的高度。随后，克莱斯勒将它的光辉历史抛在身后，将总部搬到荷兰，并更名为FCA US LLC。
Antiviral drug discovery: broad-spectrum drugs from nature
其他数个政党的支持率只是略低于上述两党，包括持中间立场的自由派政党民主66 (D66)、基督教民主联盟(Christian Democratic Appeal)和左翼的绿色左翼党(GreenLeft)。
出手阔绰的美国公司正迫使英国同行提高从新入行者到顶级风云人物的薪资——尽管这并未阻止富尔德(Freshfields)的私募股权明星戴维希金斯(David Higgins)在圣诞节前夕跳槽到凯易律师事务所(Kirkland & Ellis)。精品专业律所通过提供更快、更专注的服务来吸引客户。
Nine provincial-level regions' GDP exceeded 3 trillion yuan in 2016, three more than the year before. The number of provincial-level areas with GDP surpassing 1 trillion yuan in 2016 remained 25.
Influenza neuraminidase: A druggable target for natural products
“The Man Who Knew is an impressive work of scholarship,” Lionel Barber, editor of the FT and chair of the book award judges, said. “It’s a masterpiece of political economy and, above all, it’s a great and enjoyable read.”
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
We will promote coordinated urban development above and below the ground, and begin construction on at least another 2,000 kilometers of underground utility tunnels in cities. A three-year initiative will be launched to remove the risk of flooding in highly vulnerable urban areas; and further progress will be made in the development of sponge cities. All these efforts will make our cities more attractive and function better.
The role of biosensors in the detection of emerging infectious diseases
Yes. There are plenty of positives: earnings, economic growth, and US tax cuts. But they are already known. Stocks look ridiculously expensive by historical standards, but that tells us nothing about short-term moves. Ultimately, it comes down to liquidity, which has driven markets since they emerged from the crisis in 2009. If all goes according to plan, central banks will be decreasing their balance sheets, and removing liquidity, by the end of 2018. If they go through with this, the odds are that the S&P will stall. But even a tiny tremor could make the bankers blink. Expect the momentum to continue.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Kristen Stewart definitely did some 'butt' kicking at the Nickelodeon Kids' Choice Awards 2013 on Saturday. The star strutted down the purple carpet in a dazzlingly deep blue and black top and tiny shorts that had a miniscule checkerboard pattern. Kristen was nominated for two awards at the live show - Favorite Movie Actress for The Twilight Saga: Breaking Dawn - Part 2 and Favorite Female Buttkicker for Snow White and the Huntsman.
The requirements come from one of two newly issued regulations over the taxi and online ride-hailing services by China's transportation authority. The regulations will take effect in October and November respectively.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
The book — published by Basic Books and Oneworld Publications — won out against a strong shortlist dominated by books on technology.
May your New Year be filled with special moment, warmth, peace and happiness, the joy of covered ones near, and wishing you all the joys of Christmas and a year of happiness.
China’s exports and imports suffered larger-than-expected drops in the first month of this year in both renminbi- and dollar-denominated terms.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Country's biggest stars gathered in Las Vegas on Sunday for the 2013 Academy of Country Music Awards.
Inhibition of SARS coronavirus helicase by bismuth complexes
There were also shows that didn’t live up to early expectations but still had traction, most notably “The Affair,” on Showtime, which began as a Hamptons film noir and instead turned into a French art film. The crime may not be commensurate with the series’s punishingly slow pace and “Rashomon"-like storytelling, but the series picked up momentum — and suspense — in the final episodes.
Once Upon A Time
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Best Companies rank: 66
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
“These students have absolutely no free speech rights that were violated in this context."
On average, executive pay packets hit 7.09 million yuan in 2016, up 8% year-on-year, higher than the rate of China's GDP and per capita disposable incomes, which were 6.7% and 6.3% respectively.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Dawn Hudson, Academy CEO:
The study was based on 3,095 questionnaires from 2016 graduates and 1,661 questionnaires from employers across the country.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
These rankings use a different methodology from the overall ranking based on academic research performance in each specific subject.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
n. 宣言，声明 vi. 发表宣言
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
珍妮弗?劳伦斯曾于去年凭藉《乌云背后的幸福线》(Silver Linings Playbook)获得金球奖，而今年再度登台领奖的她表示，获奖感言还是让她倍感紧张。
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
So ladies, we have been warned. What would your response be?
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Any decision by China’s policymakers to begin selling down the country’s huge reserves would have a large impact on markets.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
8月，为了捍卫中国在全球经济中的制造业中心的地位，央行引导人民币作出数十年来最大幅的贬值。稍后，在国际货币基金组织(International Monetary Fund)把人民币纳入全球储备货币之后，人民币进一步贬值。这一现象可能反映了资本外流。
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Song “Friends Forever” (Yang Kun and Zhang Liangying)
It is believed that the rise of South Korea's pop music industry is behind the boom, and many patients visit clinics with photos of celebrities, asking surgeons to emulate nose angle or eyes.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
与此同时，法国拉罗谢尔高等商学院(La Rochelle Business School)的排名却下滑12个位置，排在第60位，去年该学校是排名上升最快的学校之一。
No.5: What Made Phelps So Happy?
‘Unfortunately, while the newest episode may be a fantastic addition to the Star Wars franchise, ‘starwars’ is a dangerous password to use,’ said Morgan Slain, CEO of SplashData, Inc.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Peer review is an evaluation of work by one or more people of similar competence to those who produce the work, which helps validate research.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
The school is also second for its international course experience. More than four in five of its latest graduating cohort went on an internship abroad and over half studied in another country for more than a month.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
It scares/intimidates people and they don't know better anyway.
If you plan to visit Brazil for the Olympic games, and to focus on sport and having fun, Google has you covered. In anticipation of the 2016 Rio Olympics, the search giant is bringing the 'Explore' feature to Brazil Maps.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Lopez Short is the name of the game, judging from the red carpet looks of Beyoncé and Jennifer Lopez. Both divas went for thigh-high dresses to show off their gams4, with strategically cut out neck and shoulder detail, but where Beyoncé opted to stand out in fire engine red, J. Lo went for soft and satiny earth tones.
There is a salary gap of nearly 22 per cent between male and female graduates three years after they finished their courses, $90,000 compared to $73,000. That gap had been 17 per cent whenstudents first graduated, so thisdifference has widened over time(see chart).
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Elspeth Cheung, head of BrandZ valuation at Millward Brown, says: “The top 10 used to be dominated by consumer goods. This year, it’s technology.”
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
At New Year and always, may peace and love fill your heart, beauty fill your world, and contentment and joy fill your days.新年的祝福，平日的希冀，愿你心境祥和、充满爱意，愿你的世界全是美满，愿你一切称心如意，快乐无比。
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
In a vote by Sina Weibo，China's Twitter-like website, 58.5 percent of people "liked" the ink painting version of the monkey, only 14.4 percent like the front view of the 3D version, while 12.5 percent want to "change its clothes", supposedly meaning they don't like the colors.
AFI TV Programs of the Year
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
When you think of him, your heart would jump between fast and fast.
adj. 全国流行的 n. (全国或全世界范围流行的)疾
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
In global health, 2016 will be remembered as the year a little known virus made a major impact. It felt strangely familiar, but this time it wasn't Ebola making headlines around the world, it was Zika - a mosquito-borne virus being linked to a huge spike in the number of babies in Brazil born with brain defects.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The banking industry has been experiencing a low profit growth period and will be for a long time, the National Business Daily reported, citing an expert. He said the banks' yearly profits growth reached 35 to 40 per cent in the past dozen years, but now the growth had slowed to less than 1 per cent, with some banks even recording a loss.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
10. Computer systems analyst
Anti-HIV drug repurposing against SARS-CoV-2
“One guy hired a marching band to accompany his announcement.”
Length-scale dependence of protein hydration-shell density
China has fully complied with UN resolutions on the denuclearization of the Korean Peninsula, and is a staunch supporter of upholding the international nuclear non-proliferation regime.
Americans: While you're here, why not pretend to be Canadian? Very few Britons can tell the difference, and it will allow you to rescue yourself from awkward conversations about the death penalty.
You will ignore others when you are together.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
But the best answer to the Oscar statue display question comes from Timothy Hutton, the youngest person ever to win the Academy Award for best supporting actor. Hutton, who won the gold figurine for his role in Ordinary People, was apparently having a party a number of years ago. His sister popped the Oscar in the fridge alongside the beers so that guests would happen upon it en route to refreshment. The statue is apparently still in there.
Most of Friends was shot before cellular phones and Google were ubiquitous. The clothes and gadgets seem a bit outdated these days. Despite this, the show’s key elements still hold up remarkably well in the eyes of young viewers.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
An iPhone displays an image of Steve Jobs as it sits with a memorial to the Apple founder and former CEO outside an Apple Store, Wednesday, Oct. 5, 2011 in New York. Jobs passed away Wednesday at the age of 56
Of the large land areas where many people live, only the eastern portion of the United States recorded below-average temperatures in 2014, in sharp contrast to the unusual heat in the West. Some experts think the weather pattern that produced those American extremes is an indirect consequence of the release of greenhouse gases, though that is not proven.
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Good health, good luck and much happiness throughout the year.
Despite such arguments from a handful of scientists, the vast majority of those who study the climate say the earth is in a long-term warming trend that is profoundly threatening and caused almost entirely by human activity.